We have uncovered several novel genes associated with progressive and/or late-onset hearing loss, including solute carrier family 4, sodium bicarbonate transporter, member 10 (Slc4a10), Wars2, protein tyrosine phosphatase, receptor type, Q (Ptprq) and zinc finger, FYVE domain containing 26 (Zfyve26). The gene discussed is PTPRQ; the disease is hearing loss disorder.