TGFBR3 and adrenal cortex carcinoma: Furthermore, binding of MYB protein to the translocated enhancers in the NFIB and TGFBR3 loci, creates a positive feedback loop that fuels further expression of MYB. Interestingly, the mechanisms of enhancer-driven overexpression of MYB are not limited to ACC, as an analogous event has been recently described in angiocentric gliomas, which harbor MYB-QKI rearrangements.