Comprehensive genetic studies identified low rates of somatic mutations in ACC tumors (0.3 somatic mutations per 1 Mb) with wide mutational diversity scattered among genes involved in chromatin remodeling, DNA damage/checkpoint, FGF-IGF-PI3K, Rho family, axonal guidance, Notch and MYB-MYC signaling pathways [15, 71, 74, 75]. The gene discussed is MYB; the disease is adrenal cortex carcinoma.