STAT6 and colorectal carcinoma: On the contrary, IL-13 could not activate STAT6 phosphorylation or induce an EMT phenotype in Caco2 cells (Figure 4D), a STAT6null CRC cell line reported in previous study [36], While ectopic expression of STAT6 obviously increased ZEB1 expression and induced EMT phenotypes in Caco2 cells exposed to IL-13 (Figure 4E).