In this study, we find that IL-13 induces cellular morphological changes in human CRC cell lines HT29 and SW480 that are concomitant with up-regulated expression of mesenchymal marker Vimentin and down-regulated expression of epithelial marker E-cadherin, suggesting that IL-13-treated cells undergo EMT-related changes. This evidence concerns the gene CDH1 and colorectal carcinoma.