Since we found BMI-1 to repress EphA7 in neural cells and lymphocytes and given that high BMI1 expression levels have been reported in two brain tumor types (medulloblastoma and glioblastoma, [43, 44]) and that the secreted form of EPHA7 functions as tumor suppressor in human follicular lymphoma [34], we asked if high BMI-1 levels might be a cause for the silencing of EPHA7 in these tumor types. The gene discussed is BMI1; the disease is neoplasm.