After adjusting seven prognostic factors (age at diagnosis, tumor size, lymph node involvement, Ki67 expression, HER2 status, menopause status when receiving TAM and adjuvant chemotherapy), the statistical difference remained (adjusted HR = 0.17, 95% CI = 0.05~0.57, P = 0.004; Table 1, Figure 2). The gene discussed is ERBB2; the disease is neoplasm.