CDH1 and gastric cancer: To further evaluate the impact of O-mannosylation in E-cadherin, we investigated the expression of O-mannosyl glycans in two distinct gastric cancer cell lines with different E-cadherin expression patterns: MKN28 gastric cancer cell line which display normal E-cadherin expression, and Kato III gastric cancer cell line which exhibit an abnormal E-cadherin expression [38–40].