Inhibition of Wnt signaling using Dickkopf-related protein 1 (Dkk1) suppressed GC cell proliferation, wound healing, and invasion ability in cells transfected with empty vector significantly more than in cells with Barx2 overexpression, indicating that Wnt/β-catenin signaling is a key target of Barx2 during GC tumorigenesis. Here, DKK1 is linked to gastric cancer.