Barx2 increased expression of both ESR1 isoforms, the estrogen-responsive genes (SOX5, RBM15 and Dynein), the tissue inhibitor of metalloproteinase (TIMP) genes (TIMP1 and TIMP3), and MMP-9, all of which promote breast cancer cell growth, survival, and invasion [17]. This evidence concerns the gene MMP9 and breast carcinoma.