Our results showed FOXC1 promotes melanoma cell functions in vitro, such as growth, migration, invasion, colony formation et al. To check molecular mechanism of FOXC1 function in melanoma, RNA-Seq was done using mRNA from M219 control and M219 FOXC1, M15 control and M15 FOXC1, Wp-0614 control and Wp-0614 FOXC1 shRNA, M14 control and M14 FOXC1 shRNA. This evidence concerns the gene FOXC1 and melanoma.