We found a weak but significant positive correlation between mRNA levels (z-score values) of MGMT and TP53 in CCLE panel of human glioma cell lines harboring wt or mutp53 (n = 42, Spearman's rho = 0.36, p value = 0.02) (Supplementary Table S1), suggesting a potential specific relationship between MGMT and p53 in primary brain tumors, compared to other types of cancer. This evidence concerns the gene TP53 and central nervous system cancer.