There was a significant correlation between mRNA levels of MGMT and TP53 in wtp53 glioma cell lines (n = 17, Spearman's rho = 0.55, p value = 0.024), but not between mRNA levels of MGMT and TP53 in mutp53 glioma cell lines (n = 25). This evidence concerns the gene TP53 and central nervous system cancer.