Taken our results and given a report on embryonic kidney HEK293 cells, where Ephrin B3 was required to prevent caspase-mediated EphA4 cleavage and subsequent apoptosis, we speculate that Ephrin B3 may exert such a function on EphA4 in NSCLC cells [25]. The gene discussed is EPHA4; the disease is non-small cell lung carcinoma.