Given that heterodimers of EphA2 and EGFR do exist in tumor cells [27], one may speculate that by altering the EphA2 interactome Ephrin B3 may influence such EphA2/EGFR heterodimers and in this way control Akt Ser 129 and EphA2 Ser897, resulting in block of EphA2 mediated invasion/migration signaling. This evidence concerns the gene EFNB3 and neoplasm.