On the other hands, siRNA-mediated inhibition of HR genes including BRCA2, RAD51C, FAAP20 or FANCD2 increased POLQ expression in mRNA and protein levels (Figure 5A to 5C), taken together, suggesting that POLQ expression correlated inversely with HR activity, and lung cancer cells with higher-POLQ expression may be companied with HR deficiency, which is agree with the findings in epithelial ovarian cancer cells reported by Cacceldi et al [44]. The gene discussed is FANCD2; the disease is lung carcinoma.