Given the diverse roles of the Akt isoforms in different types of cancer, we tested the hypothesis that Akt isoform-specific ablation in mouse epithelial ovarian cells (ID8) will have diverse effect on tumor size, survival and metastasis in a wild-type orthotopic syngeneic C57Bl/6 mouse model that replicates high grade serous ovarian carcinoma [19] and that Akt isoforms in the tumor microenvironment contribute differently to tumor progression. The gene discussed is AKT1; the disease is cancer.