Infection of macrophages with M. tuberculosis H37Rv (represented as H37Rv), multi-drug resistant strain MDR-JAL2287, M. tuberculosis H37Ra (represented as H37Ra) or M. bovis BCG (represented as BCG), but not M. smegmatis, displayed JMJD3-dependent LB formation. The gene discussed is KDM6B; the disease is infection.