CXCL2 and infection: Interestingly, while JMJD3 was found to negatively regulate few of the mycobacteria-responsive M1 markers of macrophages viz., Il12, Il1b and Cxcl2 (S2A Fig), the expression of M2 markers like Arg1, Mrc1, Il10, Tgfb, Ccl17 and Ccl2 on infection were JMJD3-dependent (Fig 1K).