Reduced levels of pregnancy associated plasma protein A (PAPP-A) and placental growth factor (PlGF) around 8 to 14 weeks of gestational age are associated with obstetric complications such as preeclampsia, small-for-gestational age (SGA), intra-uterine growth restriction (IUGR) and stillbirth [1–3]. This evidence concerns the gene PGF and fetal growth restriction.