DYRK2 and neoplasm: A strong correlation occurred between DYRK2 expression (determined by using IHC staining), and clinicopathologic characteristics of these CRC patients, including tumor site (P = 0.023), clinical stage (P = 0.006), Nodal (N) classification (P = 0.017), Metastasis (M) classification (P = 0.004), and mortality (P < 0.001) (Table 4).