Host pathways involved in the antiviral response (Influenza A, cytosolic DNA sensing, toll like receptor signaling, HIV/Nef), the inflammatory response (IL22BP, IL10, IL-12, African trypanosomiasis, inflammatory bowel disease, and TNFR1), and cell death/apoptosis response (Fas, lysosome, chemical) were identified as the most accurate predictors to distinguish between asymptomatic and symptomatic subjects. The gene discussed is S100B; the disease is human African trypanosomiasis.