We did note a modest, but nonetheless statistically significant decrease in cell size for both HPB-ALL and TALL-1 after treatment with CP-751,871 (Fig 3C), and that myrAKT induced an increase in cell size which was not seen as robustly with RAS(G12D) (Fig 3D and S6 Fig). This evidence concerns the gene TNFSF13B and acute lymphoblastic leukemia.