Interestingly, a constitutively active myristoylated AKT (myrAKT) construct rescued HPB-ALL cells from CP-751,871-induced growth inhibition to an extent on par with a constitutively active CD8-IGF1R fusion protein[29] which we employed as a positive control in this assay (Fig 3A and S6 Fig). The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.