As well, we and others have reported previously that IGF1R is upregulated both transcriptionally[4, 14] and post transcriptionally[15] in T-ALL by NOTCH1, a prominent oncogene in the disease[1], and that IGF signaling contributes to growth/survival of bulk cells and also to leukemia-initiating activity[4]. The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.