The DDAVP test was performed in 10 normal-platelet-VWF and 8 low-platelet-VWF patients with mild type 1 VWD to examine the contribution of VWF survival in regulating plasma VWF levels: the normal-platelet-VWF patients revealed a statistically lower VWF T1/2elimination (T1/2el) than the low-platelet-VWF patients (5.3+/-2.0 h vs 9.1+/-4.2 h, p<0.05), and a faster clearance (CL) (5.95+/-2.1 h vs 3.72+/-1.8 h, p<0.005) (Fig 2). Here, VWF is linked to von Willebrand disease 1.