In the low-platelet-VWF mild type 1 VWD group, 32 patients from 17 unrelated families underwent genetic investigations and VWF mutations were identified in all but one: 71% were missense mutations (the most common being the c.7085G>T, p.C2362F—found in 3/17 families) (Table 2), while the other 29% were null mutations, i.e. nonsense nucleotide substitutions or deletions inducing a frameshift with a premature stop codon, the most common being the c.1534-3C>A mutation (in 2/17 families). Here, VWF is linked to von Willebrand disease 1.