For other forms of type 1 VWD, a correlation is apparent between a rising FVIII/VWF:Ag ratio and falling platelet VWF levels, since patients with severe type 1 VWD had the most pronounced increase in their FVIII/VWF:Ag ratio, while it was nearly normal in patients with normal-platelet-VWF mild type 1 VWD. This evidence concerns the gene F8 and von Willebrand disease 1.