Some differences in the FVIII/VWF:Ag ratio emerged, since it appeared to be almost normal in normal-platelet-VWF mild type 1 VWD (1.3+/-0.1), but higher than normal in low-platelet-VWF patients (1.9+/-0.2), the normal range being 0.75–1.2 (Table 1). This evidence concerns the gene VWF and von Willebrand disease 1.