CD274 and neoplasm: Based on the findings in KEYNOTE 001 (Fig. 1), it may make more sense to consider PD-L1 expression as a continuous measures rather than a binary “positive” or “negative.” Along these lines, currently published tissue studies have found PD-L1 positivity to indicate favorable, unfavorable, or have no relationship to prognosis, as well as variable correlations with histology and mutation status in NSCLC and other tumor types [22–32].