CD274 and non-small cell lung carcinoma: In this review, we will describe the recent data leading to the FDA approvals of nivolumab (Opdivo, approved in December 2014 and March 2015 for non-squamous and squamous NSCLC in the 2nd line setting) and pembrolizumab (Keytruda, approved in October 2015 for PD-L1 positive NSCLC also in the 2nd line setting).