In the present study, we aimed to evaluate the association of six previously identified polymorphisms, PNPLA3 rs738409, rs2294918, NCAN rs2228603, GCKR rs780094, LYPLAL1 rs12137855, and TM6SF2 rs58542926, with NAFLD in a community-based Han Chinese population. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.