Given that the sample size and alleles frequencies of our study (n = 766, MAF = 0.45) were comparable to the previous study (n = 797, MAF = 0.49) (Lin et al., 2014), we speculated that GCKR rs780094 may only have a moderate effect on NAFLD incidence in Chinese population. Here, GCKR is linked to metabolic dysfunction-associated steatotic liver disease.