We analyzed a short 500-bp region from the human c-MYC promoter between P0 and P1 that represents a major breakage hotspot found in c-MYC translocation-induced lymphomas and leukemia (Care et al., 1986; Haluska et al., 1988; Joos et al., 1992; Saglio et al., 1993; Wilda et al., 2004). This evidence concerns the gene MYC and lymphoma.