The co-localization of non-B DNA-forming sequences and chromosomal breakpoints identified in the c-MYC and BCL-2 genes in translocation-related cancers (Figure 1), and a genome-wide significant enrichment of non-B DNA-forming sequences at genomic breakpoints in human cancer (Bacolla et al., 2016) suggest a role for non-B DNA in genetic instability and cancer development. This evidence concerns the gene BCL2 and cancer.