TLR5 and colitis: However in another study, in which DSS-colitis-induced mice lacking expression of TLR5 by either intestinal epithelial cells [TLR5(DeltaIEC)] or DCs [TLR5(DeltaDC)] were examined for basal phenotypes in response to a high-fat diet and pathobiont challenge, microbiota composition was found to cluster more closely according to genotype than housing (572).