Along with PKC, PKA may catalyze phosphorylation of PLM at Ser68 (Fuller et al., 2004, 2009) in response to ischemia or β adrenergic stimulation (Despa et al., 2005) causing release of the inhibitory action of association of the FXYD1 subunit with the Na,K-ATPase. The gene discussed is FXYD1; the disease is ischemia.