Also, expression of ARE-driven genes, such as NAD(P)H dehydrogenase, quinone 1 (NQO1) and heme oxygenase (decycling) 1 (HO-1), is increased in brain tissue in a Parkinson’s disease (PD) mouse model (Jing et al., 2015), which could be a neuroprotective response mediated by NFE2L2 activation. Here, HMOX1 is linked to Parkinson disease.