To further investigate whether lal−/− MSC-CM activates oncogenic intracellular signaling, a hallmark of tumor proliferation, tumor cells were treated with lal+/+ and lal−/− MSC-CM, and intracellularly stained with anti-phospho-AKT, anti-phospho-ERK1/2, anti-phospho-NF-κB, anti-phospho-STAT3, or anti-phospho-P38 antibodies. The gene discussed is STAT3; the disease is neoplasm.