The importance of AKT in cancer has been studied and allosteric AKT inhibitors such as MK2206 have been studied in various early phase clinical trials [16–22, 27, 28] We verified the critical role for AKT in driving cell growth in the PPP2R2A mutant leukemic blasts by treating the cells with the AKT inhibitor, MK2206. This evidence concerns the gene AKT1 and cancer.