In contrast, no differences were observed at Braak stages I–II to V. We also determined the Reelin expression in the hippocampus by qRT-PCR at Braak stages IV to VI (the only tissue available from our collection) and again, Reelin mRNA was expressed more strongly in the AD hippocampus at these stages that in the ND tissue (p = 0.02; Fig. 3b). The gene discussed is RELN; the disease is Alzheimer disease.