Insect Hsp genes might be regulated by the RNAi pathway, another mechanism that plays important roles in antiviral defense39, 40 and has been proven to affect survival, infection and transmission of rice reoviruses and their interactions with leafhopper and planthopper vectors21, 41, 42, and this defense mechanism can also be suppressed by viruses43. This evidence concerns the gene HSP90B2P and infection.