Recently, the pretransplant AFP slope has been reported to be a novel predictor of HCC recurrence after liver transplantation.48 Nevertheless, this was not confirmed by several other studies, including that of the authors of this manuscript.49,50 However, the last pretransplant AFP also provides a dynamic assessment of patients eligibility for transplantation, as the AFP values are subject to spontaneous or neoadjuvant treatment-related changes in the pretransplant period. The gene discussed is AFP; the disease is hepatocellular carcinoma.