The level of circulating ICsis low in acutely infected patients, whereas chronically infected individuals show a highproportion of immunocomplexed HCV, raising the possibility that ICs may have a role in thepathogenesis of HCV, namely liver damage.91 Moreover,the formation of ICs with non-neutralizing antibodies may also lead to theantibody-dependent enhancement of viral infection of FcγR-expressing cells. Here, FCGR2A is linked to viral infectious disease.