Epigenetic disruptions in FSHD include chromatin relaxation through the SMCHD1 or DNMT3B gene defect causing FSHD type 2 (FSHD2) [13, 27], hypomethylation [14], alternative RNA splicing and nucleosome remodelling [15]. This evidence concerns the gene SMCHD1 and facioscapulohumeral muscular dystrophy.