As shown in Fig. 3b–d, TgDNMT1 notably increased the proinflammatory cytokines (e.g., TNFα, IL-1β and IL-6) and decreased IL-10 levels in the plasma, epididymal fat tissues and livers of ApoE−/− mice that were fed an AD for 12 weeks. This evidence concerns the gene APOE and Alzheimer disease.