Two major strengths of our study are the collection of unbiased high-quality mRNA-Seq data from samples of a well-characterized cohort of measles vaccine recipients (after two doses of MMR vaccine and no wild type measles virus exposure), and our statistical (gene-to-biology and biology-to-gene) and bioinformatics approaches, which enabled us to identify specific genes (e.g., CD93, IL24, IL6, CXCL12), pathways and processes (e.g., cell adhesion and migration, cytokine/chemokine activity and regulation, inflammatory response) and network components that are biologically relevant. This evidence concerns the gene CXCL12 and measles.