Among the tumor tissue and cfDNA pairs, we identified COSMIC listed mutations in various kinases, including PIK3CA, ALK, MAP2K3, and PAK2. We further detected a splice site variant in the tumor suppressor gene PTEN. Moreover, cfDNA confirmed variants in LRP1B, MET, and the epigenetic modulator KMT2C. Apart from confirming variants detected in tumor tissues, cfDNA revealed additional variants of clinical relevance. This evidence concerns the gene LRP1B and neoplasm.