Another, unusual, neuromuscular phenotype consists of a clinical entity belonging to the heart-hand syndrome family: the disease was first described in 2005 [65] and recognized as a laminopathy three years later [66]: the authors described a large Slovenian family whose affected members developed from the fourth and fifth decade the typical cardiac compromise that is LMNA gene-related, with ECG abnormalities, progressive rhythm conduction defects and late dilated cardiomyopathy. Here, LMNA is linked to laminopathy.