Of note, atypical phenotypes include also overlapping syndromes obtained by the co-occurrence in the same subject of different diseases caused by the same pathogenic variation on the lamin A/C gene; metabolic alterations in association with skeletal and/or cardiac alterations proved to be the most frequent overlap syndromes: familial partial lipodystrophy, hepatic steatosis or only hypertriglyceridemia can be associated with dilated cardiomyopathy with conduction defects, with or without muscular dystrophy [67]. The gene discussed is LMNA; the disease is muscular dystrophy.