LMNA and Ventricular arrhythmia: Furthermore, recent studies have demonstrated how sustained malignant ventricular arrhythmias tend to occur in subjects bearing at least two of the following variables: the status of carrier of a LMNA gene mutation other than missense, the male gender, a previous history of non-sustained ventricular arrhythmias and an ejection fraction less than 45% at the first cardiac detection [62].