BCL2 and breast carcinoma: Besides, carnosic acid markedly induced TRAIL-mediated apoptosis in human renal carcinoma, human hepatocellular carcinoma, and human breast carcinoma cells, through down-regulating c-FLIP and Bcl-2 expression, and up-regulating ER stress-mediated DR5, Bim, and p53 up-regulated modulator of apoptosis (PUMA) expression at the transcriptional levels, without affecting normal cells [223].