In another study, it was validated that curcumin treatment to human lung cancer cells could induce DNA damage and inhibit expression of DNA-repair-associated proteins, such as breast cancer susceptibility gene 1 (BRCA1), 14-3-3 protein σ, O6-methylguanine-DNA methyltransferase (MGMT), and mediator of DNA damage checkpoint 1 (MDC1) [39]. This evidence concerns the gene MDC1 and lung cancer.