In addition, constitutive and interleukin (IL)-6-induced STAT3 activation were reduced, and constitutive and TNF-α-induced NF-κB activity were inhibited by 6-shogaol in human (LNCaP, DU145, and PC3) and mouse (HMVP2) prostate cancer cells. The gene discussed is NFKB1; the disease is Familial prostate cancer.