GSK3B and neoplasm: In another study, tumor growth in ApcMin (Min, multiple intestinal neoplasia) mice was interfered by thymoquinone through inducing tumor-cell specific apoptosis and modulating Wnt signaling via activation of glycogen synthase kinase (GSK)-3β, indicating Nigella sativa oil (or thymoquinone) might be useful as nutritional supplement in familial adenomatous polyposis [111].