Adding to the controversy, Sherva et al. studied MMP-3 polymorphisms in 39,114 patients from the United States, Canada, Puerto Rico, and US Virgin Islands in the Genetics of Hypertension Associated Treatment study and conversely found the 6A/6A genotype to be associated with higher IS incidence in patients randomized to take lisinopril for hypertension [87]. This evidence concerns the gene MMP3 and Hypertension.