In colorectal cancer EMT is induced by PLS3 via TGFβ-signaling cascades, resulting in invasive properties of cancer cells [56], but also special tumor treatments were shown to promote metastasis: in hepatocellular cancer, transcatheter arterial embolization is a common palliative treatment, but it was shown that it simultaneously upregulates hypoxia-inducible factor 1a (HIF1a) and epithelial to mesenchymal marker proteins like N-cadherin and vimentin thereby stimulating the metastatic potential of tumor cells [57]. This evidence concerns the gene HIF1A and neoplasm.