It was shown that overexpression of human kallistatin in the retina of Akita mice, significantly decreased the expression of pro-angiogenic factors such as VEGF, intercellular adhesion molecule (ICAM)-1 as well as the number of CD11+ b leukocytes suggesting that overexpression of kallistatin suppressed Wnt signaling induced by ischemia or diabetes [105]. Here, SERPINA4 is linked to diabetes mellitus.