For example, RSR-13 and several of its analogs that bind to the central water cavity of Hb and significantly decrease Hb affinity for oxygen (∆P50 of 20–30 mmHg at 2 mM) have been the subject of investigation for stroke, wound healing, and as a radiation enhancer in the radiotherapy of hypoxic tumors, adjuncts for Hb based oxygen carriers, nitric oxide, carbon monoxide and other non-oxygen therapeutic gases [50,51,52,53,54,55,56,57]. Here, GSTM1 is linked to Stroke.