Using this approach, MHCI protein turnover rates were determined in KG-1 cells, an acute myeloid leukemia cell line, which has been used in studies of MHCI post-translational fate and B27 misfolding [34, 52] and as a model of differentiation into dendritic cell-like phenotypes [53]. The gene discussed is MRAP; the disease is acute myeloid leukemia.