The ELA group exhibited increases in alveolar neutrophil infiltration, the numbers of TNF-α, MAC-2, MMP-9, MMP-12, TIMP-1, eNOS, and iNOS-positive cells and the volume fraction of the 8-iso-PGF2 α, suggesting the presence of lung inflammation, remodeling, and oxidative stress processes. The gene discussed is NOS3; the disease is inflammation.