It's worth noting that sporadic HNSCC that develop in the general population has relationship with inactivation of these genes (TP53, p16, FANCA-M) or aberrant expression of the members of these oncogenes (ras and myc gene family, int-2, hst-1, cyclin D1, epidermal growth factor receptor and Bcl-2) [112]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.