FGF3 and head and neck squamous cell carcinoma: 11q13 is a region that contains several genes(CCDN1, EMS 1, FGF3 and FGF4) previously shown to be amplified and overexpressed in HNSCC patients, while studies concluded that 11q13 amplification was significantly more frequent in smokers, which suggested that gains in this region may have no relationship with ages of patients [104].