Secondarily, the observation that at 24 weeks, the preservation of 15-PGDH—a PG degrading enzyme—accompanied with attenuated COX-2, VEGF, PDGF, and CD31 expression in Fat-1 TG mice compared to WT mice strongly explained the cancer-preventive actions of ω-3 PUFAs [36]. Here, VEGFA is linked to cancer.