CAVIN1 and lipodystrophy: On the other hand and given that the lipodystrophy of PTRF/Cavin-1 null mice and humans has a progressive severity, PTRF’s eponymous function in rRNA synthesis does indeed provide a possible explanation whereby decreased rRNA transcription as a function of time would lead to adipocyte loss due to the inability to maintain adequate protein levels, and we present data here in support of this hypothesis.