Additionally, in humans, mutations in BUB1B have been causally implicated in MVA, a rare clinical syndrome characterized by widespread aneuploidy, growth retardation, shortened lifespan, and cancer predisposition (García-Castillo et al., 2008; Hanks et al., 2004; Matsuura et al., 2006; Wijshake et al., 2012). Here, BUB1B is linked to cancer.