BUB1B and cancer: Complete loss of BubR1 causes early embryonic death (Wang et al., 2004), and while BubR1 hypomorphic (Bub1bH/H) mice are viable, they develop a variety of premature aging phenotypes (Baker et al., 2004; Hartman et al., 2007; Kyuragi et al., 2015; Matsumoto et al., 2007; North et al., 2014), progressive aneuploidy (Baker et al., 2004), and are predisposed to carcinogen-induced cancers (Baker et al., 2006).