On the other hand, p300 enhance activation indirectly by epigenetic reprogramming of histone marks [64], increasing H3K27 acetylation, an epigenetic mark associated to higher transcription activity, which could explain lower activation of gene expression in relevant cancer cell lines that likely lack endogenous drivers of TSGs, in contrast with a normal-like cell such as HEK293T. Here, EP300 is linked to cancer.