Differential EMP3 mRNA expression was observed in gliomas, with the highest expression seen in GBMs (GBMs Vs non-tumor, P < 0.0001; GBM Vs grade II or grade III astrocytomas/oligodendrogliomas, P < 0.05; Grade II astrocytomas Vs non-tumor, P < 0.05. Here, EMP3 is linked to central nervous system cancer.