The Cox Hazard model and the Hosmer-Lemeshow confirmation test, once corrected for each applicable data (age, gender, body mass index (BMI), single or clustered risk factors including smoking habit, CV medications, LOX-1 polymorphism, TKI treatment) available at the time of occurring event or at the time of clinical observation if event-free, showed that the cluster of co-existing nilotinib treatment, dyslipidaemia and the G allele of LOX-1 polymorphisms was the only significant finding associated with events (H.R. 2.19 95% C.I. 1.66-2.99, p < 0.001) (Figure 1). Here, OLR1 is linked to inherited lipid metabolism disorder.