Thus, to elucidate a potential pathogenic link between TKIs treatment and mechanisms underlying PAOD or other atherothrombotic events, we investigated, in a series of CML patients treated with nilotinib and imatinib, the correlation between LOX-1 polymorphisms, the presence of classic CV risk factors and vascular events. This evidence concerns the gene OLR1 and chronic myelogenous leukemia, BCR-ABL1 positive.