CD40LG and atherosclerosis: Furthermore, during treatment with either TKIs, we studied a selected pro-atherothrombotic biochemical profile evaluating the following: 1) coagulation state by Endogenous Thrombin Potential (ETP); 2) specific circulating mediators of inflammation such as IL-10, IL-6 and TNFα; 3) high-sensitivity C-reactive protein (hs-CRP) previously proven to be involved in the atherothrombosis burden [22–27]; 4) ox-LDL as metabolic effectors of atherosclerosis predisposition [22, 23, 25]; 5) soluble CD40 ligand (sCD40L) as a marker of platelet derived-inflammation and platelet activation trigger [22, 28].