TP53 and cancer: Known factors, which lead to lncRNA dysregulation in cancer, include copy number alteration due to gene rearrangement such as deletion and amplification, cancer-linked single nucleotide polymorphism (SNP) occurred in lncRNA coding gene, epigenetic changes occurred in imprinted loci where lncRNA is embedded or changes of DNA methylation state occurred in promoter region of lncRNA, and transcriptional regulation via transcription factor such as oncoprotein MYC or tumor suppressor p53 [reviewed in ref.4].